• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

核酸与蛋白质相互作用的模型研究：酰胺与核酸碱基的氢键作用。

Model studies of interactions between nucleic acids and proteins: hydrogen bonding of amides with nucleic acid bases.

作者信息

Lancelot G, Hélène C

出版信息

Nucleic Acids Res. 1979 Mar;6(3):1063-71. doi: 10.1093/nar/6.3.1063.

DOI:10.1093/nar/6.3.1063
PMID:440968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC327753/
Abstract

The formation of hydrogen bonded complexes between nucleic acid bases and acetamide has been studied by nuclear magnetic resonance in CDC13 at different temperatures. Pairs of hydrogen bonds are formed when acetamide binds to nucleic acid bases. Thermodynamic parameters have been computed and compared to those obtained for the association of carboxylic acids with nucleic acid bases. The role of hydrogen bonded complexes in the association of proteins with nucleic acids is discussed.

摘要

通过在不同温度下于CDCl₃中进行核磁共振研究了核酸碱基与乙酰胺之间氢键复合物的形成。当乙酰胺与核酸碱基结合时会形成氢键对。已计算出热力学参数，并与羧酸与核酸碱基缔合所获得的参数进行了比较。讨论了氢键复合物在蛋白质与核酸缔合中的作用。

相似文献

1
Model studies of interactions between nucleic acids and proteins: hydrogen bonding of amides with nucleic acid bases.核酸与蛋白质相互作用的模型研究：酰胺与核酸碱基的氢键作用。
Nucleic Acids Res. 1979 Mar;6(3):1063-71. doi: 10.1093/nar/6.3.1063.
2
Dynamic properties of interaction between nucleic acid bases and models of amino acids.
Biochem Int. 1989 Jan;18(1):189-95.
3
Effect of protein side chain amide group on the hydrogen-bond equilibrium in nucleobases studied by infrared and 13C-NMR spectroscopy.通过红外光谱和13C核磁共振光谱研究蛋白质侧链酰胺基团对核碱基中氢键平衡的影响。
Biophys Chem. 1989 Sep 15;34(1):1-8. doi: 10.1016/0301-4622(89)80035-3.
4
Models of interaction between nucleic acids and proteins. Hydrogen bonding of arginine with nucleic acid bases, phosphate groups and carboxylic acids.核酸与蛋白质之间的相互作用模型。精氨酸与核酸碱基、磷酸基团和羧酸的氢键作用。
Biochim Biophys Acta. 1979 Sep 27;564(2):181-90. doi: 10.1016/0005-2787(79)90217-x.
5
Theoretical study on the proton chemical shifts of hydrogen bonded nucleic acid bases.氢键合核酸碱基质子化学位移的理论研究
Nucleic Acids Res. 1977 Jan;4(1):99-116. doi: 10.1093/nar/4.1.99.
6
[Interaction of nucleic acids and glycans].[核酸与聚糖的相互作用]
Biofizika. 2007 May-Jun;52(3):443-51.
7
[Nuclear magnetic resonance study of C--H...O type hydrogen bonds in analogs of nucleic acid base].[核酸碱基类似物中C--H...O型氢键的核磁共振研究]
Mol Biol (Mosk). 1980 Mar-Apr;14(2):316-22.
8
Proton magnetic resonance studies of specific association of nucleic acid constitutent bases in a nonaqueous solvent. Utility of DTBN radical to probe the affinity of hydrogen bonding involved in complementary base pairs1.
J Am Chem Soc. 1977 Jun 22;99(13):4299-4305. doi: 10.1021/ja00455a016.
9
Affinity chromatography of nucleosides and nucleic acid base derivatives with nucleic acid bases or nitrobenzeneboronic acid substituted silicas.用核酸碱基或硝基苯硼酸取代的硅胶对核苷和核酸碱基衍生物进行亲和色谱分析。
Nucleic Acids Symp Ser. 1985(16):41-4.
10
DBBP: database of binding pairs in protein-nucleic acid interactions.DBBP：蛋白质-核酸相互作用中结合对数据库。
BMC Bioinformatics. 2014;15 Suppl 15(Suppl 15):S5. doi: 10.1186/1471-2105-15-S15-S5. Epub 2014 Dec 3.

引用本文的文献

1
Specific non-histone protein fractions associated with 'active' chromatin in immunized rats.与免疫大鼠中“活性”染色质相关的特定非组蛋白蛋白组分。
Mol Cell Biochem. 1982 Nov 26;49(2):119-28. doi: 10.1007/BF00242490.
2
Incorporation of various amino acids into non-histone chromatin protein fractions of spleen cells of mice immunized with IgG.用免疫球蛋白G免疫的小鼠脾细胞非组蛋白染色质蛋白组分中各种氨基酸的掺入情况。
Mol Cell Biochem. 1981 Jun 9;37(1):13-9. doi: 10.1007/BF02355883.

本文引用的文献

1
Hydrogen bonding of amino acid side chains to nucleic acid bases.氨基酸侧链与核酸碱基之间的氢键作用。
FEBS Lett. 1973 Mar 1;30(2):219-224. doi: 10.1016/0014-5793(73)80655-6.
2
Hydrogen bonding of secondary amides.
Biochim Biophys Acta. 1967 Apr 25;136(3):561-2. doi: 10.1016/0304-4165(67)90014-1.
3
An infrared study of hydrogen bonding between adenine and uracil derivatives in chloroform solution.氯仿溶液中腺嘌呤与尿嘧啶衍生物之间氢键的红外光谱研究。
J Am Chem Soc. 1967 Feb 1;89(3):496-504. doi: 10.1021/ja00979a005.
4
Sequence-specific recognition of double helical nucleic acids by proteins.蛋白质对双螺旋核酸的序列特异性识别。
Proc Natl Acad Sci U S A. 1976 Mar;73(3):804-8. doi: 10.1073/pnas.73.3.804.
5
Hydrogen bonding of amino acid side chains to nucleic acid bases.
Biochimie. 1977;59(7):587-96. doi: 10.1016/s0300-9084(77)80168-5.
6
Hydrogen bonding between nucleic acid bases and carboxylic acids.
J Am Chem Soc. 1977 Oct 12;99(21):7037-42. doi: 10.1021/ja00463a044.
7
Selective recognition of nucleic acids by proteins: the specificity of guanine interaction with carboxylate ions.蛋白质对核酸的选择性识别：鸟嘌呤与羧酸根离子相互作用的特异性
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4872-5. doi: 10.1073/pnas.74.11.4872.