N-取代氨酰基-tRNA的酶促水解 - Suppr

Suppr

超能文献

Enzymatic hydrolysis of N-substituted aminoacyl-tRNA.

作者信息

Cuzin F, Kretchmer N, Greenberg R E, Hurwitz R, Chapeville F

出版信息

Proc Natl Acad Sci U S A. 1967 Nov;58(5):2079-86. doi: 10.1073/pnas.58.5.2079.

DOI:10.1073/pnas.58.5.2079

PMID:4866985

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC223908/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/223908/5585a550e518/pnas00151-0263-a.jpg

相似文献

Enzymatic hydrolysis of N-substituted aminoacyl-tRNA.N-取代氨酰基-tRNA的酶促水解

Proc Natl Acad Sci U S A. 1967 Nov;58(5):2079-86. doi: 10.1073/pnas.58.5.2079.

Studies on the formation of transfer ribonucleic acid-ribosome complexes. II. A possible site on the 50 S subunit protecting aminoacyl transfer ribonucleic acid from deacylation.转移核糖核酸 - 核糖体复合物形成的研究。II. 50 S亚基上一个可能保护氨酰基转移核糖核酸不被脱酰基的位点

J Biol Chem. 1967 Nov 10;242(21):4939-47.

Studies on polynucleotides. LXXXVI. Enzymic hydrolysis of N-acylaminoacyl-transfer RNA.多核苷酸研究。八十六。N-酰基氨基酰转移核糖核酸的酶促水解

J Mol Biol. 1968 Aug 14;35(3):539-60. doi: 10.1016/s0022-2836(68)80013-0.

Mutant E. coli strain with temperature sensitive peptidyl-transfer RNA hydrolase.具有温度敏感性肽基转移RNA水解酶的突变大肠杆菌菌株。

Nat New Biol. 1972 Dec 20;240(103):245-6. doi: 10.1038/newbio240245a0.

Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast.酵母中N-取代氨酰转移核糖核酸的酶促水解

J Biol Chem. 1969 Nov 10;244(21):5866-73.

Action of venom phosphodiesterase on aminoacyl-tRNA from Escherichia coli.毒液磷酸二酯酶对大肠杆菌氨酰-tRNA的作用。

Biochim Biophys Acta. 1970 Sep 17;217(1):189-91. doi: 10.1016/0005-2787(70)90135-8.

The early change in E. coli leucine tRNA after infection with bacteriophage T2.感染噬菌体T2后大肠杆菌亮氨酸tRNA的早期变化。

Biochem Biophys Res Commun. 1968 Sep 30;32(6):971-6. doi: 10.1016/0006-291x(68)90123-x.

Separation of aminoacyl-transfer RNAs by polyacrylamide gel electrophoresis.通过聚丙烯酰胺凝胶电泳分离氨酰转运核糖核酸

Biochem Biophys Res Commun. 1973 Apr 2;51(3):522-8. doi: 10.1016/0006-291x(73)91345-4.

Requirement of granosine 5'-triphosphate for ribosomal binding of aminoacyl-SRNA.氨基酰 - tRNA核糖体结合对鸟苷三磷酸的需求。

Proc Natl Acad Sci U S A. 1968 Feb;59(2):554-60. doi: 10.1073/pnas.59.2.554.

Enzymatic hydrolysis of N-acyl-aminoacyl transfer RNAs.N-酰基-氨酰基转移核糖核酸的酶促水解

Cold Spring Harb Symp Quant Biol. 1969;34:493-8. doi: 10.1101/sqb.1969.034.01.055.

引用本文的文献

Binding mode between peptidyl-tRNA hydrolase and the peptidyl-A76 moiety of the substrate.肽基-tRNA水解酶与底物肽基-A76部分之间的结合模式。

J Biol Chem. 2025 Apr;301(4):108385. doi: 10.1016/j.jbc.2025.108385. Epub 2025 Mar 4.

Unveiling the Druggable Landscape of Bacterial Peptidyl tRNA Hydrolase: Insights into Structure, Function, and Therapeutic Potential.揭示细菌肽酰-tRNA 水解酶的可成药性：结构、功能与治疗潜力的新视角。

Biomolecules. 2024 Jun 7;14(6):668. doi: 10.3390/biom14060668.

Ribosome Rescue Pathways in Bacteria.细菌中的核糖体拯救途径

Front Microbiol. 2021 Mar 18;12:652980. doi: 10.3389/fmicb.2021.652980. eCollection 2021.

A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA.一种沙门氏菌毒素通过tRNA的乙酰化促进持留菌形成。

Mol Cell. 2016 Jul 7;63(1):86-96. doi: 10.1016/j.molcel.2016.05.002. Epub 2016 Jun 2.

Bacterial transfer RNAs.细菌转运核糖核酸

FEMS Microbiol Rev. 2015 May;39(3):280-300. doi: 10.1093/femsre/fuv004. Epub 2015 Mar 21.

Crystal structure of peptidyl-tRNA hydrolase from a Gram-positive bacterium, Streptococcus pyogenes at 2.19 Å resolution shows the closed structure of the substrate-binding cleft.革兰阳性菌酿脓链球菌肽酰-tRNA 水解酶的 2.19Å 分辨率晶体结构显示了底物结合裂缝的封闭结构。

FEBS Open Bio. 2014 Oct 22;4:915-22. doi: 10.1016/j.fob.2014.10.010. eCollection 2014.

Crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Thermus thermophilus HB8.嗜热栖热菌HB8肽基-tRNA水解酶的结晶及初步X射线分析

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):332-5. doi: 10.1107/S1744309113003424. Epub 2013 Feb 27.

A universally conserved ATPase regulates the oxidative stress response in Escherichia coli.一种普遍保守的 ATP 酶调节大肠杆菌的氧化应激反应。

J Biol Chem. 2012 Dec 21;287(52):43585-98. doi: 10.1074/jbc.M112.413070. Epub 2012 Nov 8.

Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase.肽酰-tRNA 水解酶的底物识别和催化的结构基础。

Nucleic Acids Res. 2012 Nov 1;40(20):10521-31. doi: 10.1093/nar/gks790. Epub 2012 Aug 25.

Crystal structure of peptidyl-tRNA hydrolase from mycobacterium smegmatis reveals novel features related to enzyme dynamics.耻垢分枝杆菌肽基-tRNA水解酶的晶体结构揭示了与酶动力学相关的新特征。

Int J Biochem Mol Biol. 2012;3(1):58-69. Epub 2012 Feb 15.

本文引用的文献

ISOLATION OF ADENOSINE AMINO ACID ESTERS FROM A RIBONUCLEASE DIGEST OF SOLUBLE, LIVER RIBONUCLEIC ACID.从可溶性肝核糖核酸的核糖核酸酶消化物中分离腺苷氨基酸酯

Proc Natl Acad Sci U S A. 1958 Sep 15;44(9):885-9. doi: 10.1073/pnas.44.9.885.

Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

J Biol Chem. 1951 Nov;193(1):265-75.

The enzymic synthesis of amino acyl derivatives of ribonucleic acid. VI. Nucleotide sequences adjacent to the ... pCpCpA end groups of isoleucine- and leucine-specific chains.核糖核酸的氨酰基衍生物的酶促合成。VI. 与异亮氨酸和亮氨酸特异性链的……pCpCpA末端基团相邻的核苷酸序列。

J Mol Biol. 1962 Aug;5:159-71. doi: 10.1016/s0022-2836(62)80081-3.

The synthesis of glycyl-L-phenylalanyl-sRNA.甘氨酰-L-苯丙氨酰-sRNA的合成

Biochim Biophys Acta. 1967 Apr 18;138(2):241-8. doi: 10.1016/0005-2787(67)90485-6.

A possible mechanism for initiation of protein synthesis.蛋白质合成起始的一种可能机制。

Proc Natl Acad Sci U S A. 1966 Mar;55(3):606-13. doi: 10.1073/pnas.55.3.606.

Studies on the mechanism of polypeptide chain termination in cell-free extracts of E. coli.大肠杆菌无细胞提取物中多肽链终止机制的研究。

Proc Natl Acad Sci U S A. 1966 Jan;55(1):162-9. doi: 10.1073/pnas.55.1.162.

The behaviour of acetylphenylalanyl soluble ribonucleic acid in polyphenylalanine synthesis.乙酰苯丙氨酰可溶性核糖核酸在聚苯丙氨酸合成中的行为

Biochim Biophys Acta. 1966 Jan 18;114(1):135-48. doi: 10.1016/0005-2787(66)90261-9.

Polypeptide chain termination using synthetic polynucleotides.使用合成多核苷酸的多肽链终止

J Mol Biol. 1965 Dec;14(2):634-9. doi: 10.1016/s0022-2836(65)80219-4.

The release of polypeptide chains from ribosomes in cell-free amino acid-incorporating systems by specific combinations of bases in synthetic polyribonucleotides.在无细胞氨基酸掺入系统中，通过合成多聚核糖核苷酸中特定碱基组合从核糖体释放多肽链。

Proc Natl Acad Sci U S A. 1965 Nov;54(5):1450-8. doi: 10.1073/pnas.54.5.1450.

Purification and properties of a potassium-activated phosphodiesterase (RNAase II) from Escherichia coli.来自大肠杆菌的钾激活磷酸二酯酶（核糖核酸酶II）的纯化及特性

Biochemistry. 1965 Jul;4(7):1319-30. doi: 10.1021/bi00883a016.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验