新生小鼠淋巴细胞性脉络丛脑膜炎病毒感染的免疫病理学。抗胸腺细胞血清对肾小球肾炎和消瘦病的影响。
Immunopathology of lymphocytic choriomeningitis viurs infection of newborn mice. Antithymocyte serum effects on glomerulonephritis and wasting disease.
作者信息
Hirsch M S, Murphy F A, Hicklin M D
出版信息
J Exp Med. 1968 Apr 1;127(4):757-66. doi: 10.1084/jem.127.4.757.
Abstract
Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.
摘要
新生小鼠注射抗胸腺细胞血清后，淋巴系统成熟延迟，使其在比正常情况更大的年龄时能够产生对淋巴细胞性脉络丛脑膜炎病毒的细胞耐受性。体液抗体的形成未受抑制，这些动物表现出循环病毒和抗体滴度均很高的矛盾现象。继而，大多数动物出现慢性免疫病理性肾小球肾炎。一些动物在1至2月龄时出现消瘦病，其特征为网状细胞增生以及广泛浸润组织和器官。
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