Ronco P, Rivière Y, Thoua Y, Bandu M T, Guillon J C, Verroust P, Morel-Maroger L
Immunology. 1981 Aug;43(4):763-70.
Immunopathological studies of the kidney, determination of circulating immune complexes and interferon blood levels were obtained in adult congenitally-athymic nude mice ((nu/nu) infected with lymphocyte choriomeningitis (LCM) virus as well as in their phenotypically-normal litter mates (nu/+). As previously reported, intracerebral or intraperitoneal infection in nu/nu mice did not induce any mortality and resulted in a carrier state characterized by persistently high levels of virus in the circulation. Interferon was present in the circulation for approximately 6 days. Circulating immune complexes were not detectable and glomerulonephritis assessed by light microscopy, electron microscopy and immunofluorescence, was either absent or very mild. These observations show that although a carrier state can be induced in adult nude mice, circulating immune complexes and glomerulonephritis do not develop. This situation is markedly different from that induced in normal Swiss mice infected at birth, which is characterized by raised levels of circulating immune complexes and development of glomerulonephritis in all infected mice.
对成年先天性无胸腺裸鼠（nu/nu）及其表型正常的同窝仔鼠（nu/+）进行了肾脏免疫病理学研究、循环免疫复合物测定和干扰素血水平测定。这些裸鼠感染了淋巴细胞性脉络丛脑膜炎（LCM）病毒。如先前报道，nu/nu小鼠的脑内或腹腔内感染未导致任何死亡，并导致一种携带状态，其特征为循环中病毒水平持续升高。干扰素在循环中存在约6天。未检测到循环免疫复合物，通过光学显微镜、电子显微镜和免疫荧光评估的肾小球肾炎不存在或非常轻微。这些观察结果表明，虽然成年裸鼠可诱导出携带状态，但循环免疫复合物和肾小球肾炎并未发生。这种情况与出生时感染的正常瑞士小鼠所诱导的情况明显不同，后者的特征是所有感染小鼠的循环免疫复合物水平升高和肾小球肾炎的发生。
