羧苄青霉素对革兰氏阴性杆菌的体外活性。
In vitro activity of carbenicillin against gram-negative bacilli.
作者信息
Bodey G P, Terrell L M
出版信息
J Bacteriol. 1968 May;95(5):1587-90. doi: 10.1128/jb.95.5.1587-1590.1968.
Abstract
The activity of a new semisynthetic penicillin, carbenicillin, was determined against 241 strains of gram-negative bacilli with the tube-dilution technique. Of 143 strains of Pseudomonas sp., 99 had a minimal inhibitory concentration of 200 to 300 mug/ml. The majority of strains of Escherichia coli and Proteus spp. were sensitive to this antibiotic, with minimal inhibitory concentrations of 25 mug/ml or less. Strains of Klebsiella sp. were quite resistant to carbenicillin. The size of inoculum had no significant effect on the minimal inhibitory concentration for Pseudomonas sp.
摘要
采用试管稀释法测定了一种新型半合成青霉素羧苄青霉素对241株革兰氏阴性杆菌的活性。在143株假单胞菌属菌株中，99株的最低抑菌浓度为200至300微克/毫升。大多数大肠杆菌和变形杆菌属菌株对这种抗生素敏感，最低抑菌浓度为25微克/毫升或更低。克雷伯菌属菌株对羧苄青霉素相当耐药。接种量的大小对假单胞菌属菌株的最低抑菌浓度没有显著影响。
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