Neu H C, Winshell E B
Appl Microbiol. 1971 Jan;21(1):66-70. doi: 10.1128/am.21.1.66-70.1971.
The activity of 6-[d(-)-alpha-carboxy-3-thienylacetamido] penicillanic acid, BRL2288, was determined against Pseudomonas aeruginosa and various gram-negative bacilli. The majority of Pseudomonas strains (89%) were inhibited by 100 mug of the antibiotic per ml. BRL2288 is twofold more active than carbenicillin against Pseudomonas at 100 mug/ml or less. Among Enterobacteriaceae tested, 87% Enterobacter and 87% of Proteus mirabilis strains were inhibited by 25 mug/ml or less. Indole-positive Proteus were inhibited by 10 mug/ml or less. Fifty-five per cent of ampicillin-resistant Escherichia coli were inhibited by 100 mug/ml. Klebsiella were uniformly resistant. BRL2288 is not hydrolyzed by most resistant Pseudomonas, but it is destroyed by the beta-lactamases of E. coli and P. mirabilis. The antibiotic shows synergy with gentamicin but not with penicillinase-resistant penicillins such as cloxacillin. Activity of BRL2288 against gram-positive organisms is two- to eightfold less than that of ampicillin or benzylpenicillin G.
测定了6 - [d(-)-α-羧基-3-噻吩基乙酰胺基]青霉烷酸（BRL2288）对铜绿假单胞菌和各种革兰氏阴性杆菌的活性。大多数假单胞菌菌株（89%）在每毫升含100微克该抗生素时受到抑制。在每毫升100微克或更低浓度时，BRL2288对假单胞菌的活性比羧苄西林高两倍。在所测试的肠杆菌科细菌中，87%的肠杆菌和87%的奇异变形杆菌菌株在每毫升25微克或更低浓度时受到抑制。吲哚阳性变形杆菌在每毫升10微克或更低浓度时受到抑制。55%的耐氨苄西林大肠杆菌在每毫升100微克时受到抑制。克雷伯菌均具有耐药性。BRL2288不被大多数耐药假单胞菌水解，但会被大肠杆菌和奇异变形杆菌的β-内酰胺酶破坏。该抗生素与庆大霉素显示协同作用，但与耐青霉素酶的青霉素如氯唑西林无协同作用。BRL2288对革兰氏阳性菌的活性比对氨苄西林或苄青霉素G低两至八倍。
