中脑缝际核损伤或5,7-二羟色胺处理对大鼠中喹哌嗪和D-芬氟拉明催乳素释放作用的影响。

Effect of midbrain raphe lesion or 5,7-dihydroxytryptamine treatment on the prolactin-releasing action of quipazine and D-fenfluramine in rats.

作者信息

Quattrone A, Schettini G, di Renzo G, Tedeschi G, Preziosi P

出版信息

Brain Res. 1979 Sep 28;174(1):71-9. doi: 10.1016/0006-8993(79)90804-7.

Abstract

The role of brain serotonin in regulating prolactin (PRL) secretion has been investigated by studying the effect of quipazine and D-fenfluramine, two serotonin-like drugs, on plasma PRL levels under various experimental conditions. Quipazine (5, 10 and 20 mg/kg i.p.) and D-fenfluramine (5, 7.5 and 10 mg/kg i.p.) induced dose-related increases in plasma PRL levels in male rats. Intraventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) or electrolytic lesion of the nucleus raphe medianus (MR), which caused a marked and selective depletion of hypothalamic serotonin levels, significantly reduced the PRL-releasing effect of both quipazine and D-fenfluramine. These results suggest that the effect of these drugs on PRL release is mediated through a serotonergic mechanism in the brain.

摘要

通过研究两种类血清素药物喹哌嗪和右旋芬氟拉明在不同实验条件下对血浆催乳素（PRL）水平的影响，探讨了脑内血清素在调节PRL分泌中的作用。喹哌嗪（腹腔注射5、10和20mg/kg）和右旋芬氟拉明（腹腔注射5、7.5和10mg/kg）可使雄性大鼠血浆PRL水平呈剂量依赖性升高。脑室内注射5,7-二羟基色胺（5,7-DHT）或中缝正中核（MR）的电解损伤导致下丘脑血清素水平显著且选择性降低，这显著降低了喹哌嗪和右旋芬氟拉明的PRL释放效应。这些结果表明，这些药物对PRL释放的作用是通过脑内的血清素能机制介导的。