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5-HT3 receptor antagonism by ondansetron does not attenuate prolactin response to d-fenfluramine challenge in healthy human subjects.

作者信息

Coccaro E F, Kavoussi R J, Cooper T B, Hauger R

机构信息

Department of Psychiatry, Medical College of Pennsylvania, Philadelphia 19129, USA.

出版信息

Psychopharmacology (Berl). 1996 Sep;127(2):108-12. doi: 10.1007/BF02805982.

DOI:10.1007/BF02805982
PMID:8888375
Abstract

Prolactin responses to d-fenfluramine (d-FEN) challenge (0.5 mg/kg PO) were examined after pre-treatment with and without the 5-HT3 receptor antagonist ondansetron (16 mg PO) in 11 physically healthy male volunteers. Compared to pretreatment with placebo, pre-treatment with ondansetron did not significantly attenuate the PRL response to d-FEN challenge. These data are consistent with other data suggesting little role for 5-HT3 receptors in the PRL response to 5-HT agonist challenge in human subjects.

摘要

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Effect of pindolol on the prolactin response to d-fenfluramine.
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