Shah R M, Burdett D N, Donaldson D
Can J Physiol Pharmacol. 1979 Nov;57(11):1229-32. doi: 10.1139/y79-185.
Pregnant hamsters were exposed to different concentrations of nitrous oxide during the period of organogenesis. Teratogenic effects were observed in a small but significant number of fetuses. Types of malformations included cleft palate, limb defects, gut herniation, and fetal edema. A dose-effect relationship was not observed. It is not clear from our observations whether the observed effect on the fetuses was due to the excess of nitrous oxide, hypoxia, or a combination of both. Comparison with published literature indicates that further studies on the effects of nitrous oxide in placental animals are needed.
在器官形成期，将怀孕的仓鼠暴露于不同浓度的一氧化二氮中。在少量但数量显著的胎儿中观察到了致畸作用。畸形类型包括腭裂、肢体缺陷、肠道疝和胎儿水肿。未观察到剂量效应关系。从我们的观察结果尚不清楚观察到的对胎儿的影响是由于一氧化二氮过量、缺氧还是两者的综合作用。与已发表文献的比较表明，需要对一氧化二氮对胎盘动物的影响进行进一步研究。
