James K, Anderson N F
Clin Exp Immunol. 1968 Mar;3(3):227-31.
The effect of prolonged treatment with anti-lymphocytic IgG raised in horses on cell mediated (homograft rejection) and humoral type immune responses has been investigated simultaneously in the same animal. The rejection of skin homografts precedes the development of circulating antibodies against alum precipitated bovine serum albumin but may follow the formation of agglutinating antibodies against sheep erythrocytes. High levels of antibodies against horse IgG are frequently detected prior to graft rejection.
对在马体内产生的抗淋巴细胞IgG进行长期治疗,对同一动物体内细胞介导的(同种异体移植排斥)和体液型免疫反应的影响已同时进行了研究。皮肤同种异体移植的排斥反应先于针对明矾沉淀牛血清白蛋白的循环抗体的产生,但可能在针对绵羊红细胞的凝集抗体形成之后出现。在移植排斥之前经常检测到高水平的抗马IgG抗体。