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抗淋巴细胞抗体对体液抗体形成影响的进一步研究。

Further studies on the effect of anti-lymphocytic antibody on humoral antibody formation.

作者信息

James K, Pullar D M, James V S

出版信息

Clin Exp Immunol. 1968 Nov;3(9):963-72.

PMID:5712059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1579013/
Abstract

The effect of 3-, 6- and 12-day courses of anti-lymphocytic IgG treatment (1 ml of 2 g/100 ml) on the primary humoral response of random bred Wistar rats has been investigated. The primary response to alum precipitated bovine serum albumin was suppressed by all these courses. In contrast however the primary response to sheep erythrocytes was suppressed by the 6-day treatment alone or by a 3-day course augmented with azathioprine treatment. Additional experiments performed in hooded rats confirm that prolonged courses of anti-lymphocytic globulin failed to exert an antidotal effect.

摘要

研究了3天、6天和12天疗程的抗淋巴细胞IgG治疗（1ml，2g/100ml）对随机繁殖的Wistar大鼠初次体液反应的影响。所有这些疗程均抑制了对明矾沉淀牛血清白蛋白的初次反应。然而，相比之下，仅6天的治疗或联合硫唑嘌呤治疗的3天疗程抑制了对绵羊红细胞的初次反应。在有头罩大鼠中进行的额外实验证实，延长疗程的抗淋巴细胞球蛋白未能发挥解毒作用。

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引用本文的文献

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Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
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THE EFFECT OF LYMPHOCYTE DEPLETION BY THORACIC DUCT FISTULA AND ADMINISTRATION OF ANTILYMPHOCYTIC SERUM ON THE SURVIVAL OF SKIN HOMOGRAFTS IN RATS.胸导管瘘导致淋巴细胞耗竭及给予抗淋巴细胞血清对大鼠皮肤同种异体移植存活的影响。
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The attachment of proteins to aldehyde-tanned cells.蛋白质与醛鞣细胞的附着。
Br J Haematol. 1961 Jul;7:299-302. doi: 10.1111/j.1365-2141.1961.tb00340.x.
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A quantitative immunochemical measure of the primary interaction between I BSA and antibody.一种对牛血清白蛋白（BSA）与抗体之间主要相互作用的定量免疫化学测定方法。
J Infect Dis. 1958 Nov-Dec;103(3):239-62. doi: 10.1093/infdis/103.3.239.
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Factors influencing the immune response. I. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intravenous injection of bovine serum albumin in rabbits.影响免疫反应的因素。I. 抗原物理状态及淋巴细胞增殖对家兔静脉注射牛血清白蛋白反应的影响
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Surg Gynecol Obstet. 1967 Jan;124(1):1-24.
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