影响免疫反应的因素。I. 抗原物理状态及淋巴细胞增殖对家兔静脉注射牛血清白蛋白反应的影响
Factors influencing the immune response. I. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intravenous injection of bovine serum albumin in rabbits.
作者信息
Pinckard R N, Weir D M, McBride W H
出版信息
Clin Exp Immunol. 1967 May;2(3):331-41.
Abstract
The degree of aggregation of bovine serum albumin has been shown to influence not only the quantity of antibody produced but also the magnitude and increase of the relative binding affinity of the antibodies. which causes massive lymphoreticular cell proliferation initiates `non-specific' factors in the immune system enabling aggregate free bovine serum albumin, which normally induces unresponsiveness or hyporesponsiveness, to induce a hyperresponsive state in rabbits. This organism not only augments antibody production but the magnitude and evolution of the relative binding affinity of the antibodies.
摘要
已证明牛血清白蛋白的聚集程度不仅会影响产生的抗体数量，还会影响抗体相对结合亲和力的大小和增加。引发大量淋巴网状细胞增殖的物质会启动免疫系统中的“非特异性”因子，使通常诱导无反应性或低反应性的无聚集牛血清白蛋白能够在兔子体内诱导高反应状态。这种物质不仅会增加抗体的产生，还会影响抗体相对结合亲和力的大小和演变。
相似文献
1
2
3
Effects of Corynebacterium parvum on immunological unresponsiveness to bovine serum albumin in the rabbit.短小棒状杆菌对兔对牛血清白蛋白免疫无反应性的影响。
Nature. 1967 Aug 19;215(5103):870-1. doi: 10.1038/215870a0.
4
The effect of reticuloendothelial blockade on antibody formation and immunologic tolerance.网状内皮系统阻断对抗体形成及免疫耐受性的影响。
Lab Invest. 1968 Jul;19(1):15-24.
5
6
The effects of single low antigen doses on immunologic responsiveness in adult rabbits.单次低剂量抗原对成年兔免疫反应性的影响。
J Immunol. 1969 Jan;102(1):100-6.
7
Systemic immunity after local antigenic stimulation of the lymphoid tissue of the gastrointestinal tract.胃肠道淋巴组织局部抗原刺激后的全身免疫
J Immunol. 1973 Dec;111(6):1906-13.
8
9
The mechanism of breakdown of immune tolerance to a protein antigen in rabbits.兔对蛋白质抗原免疫耐受的破坏机制。
Immunology. 1971 May;20(5):719-26.
10
THE CELL CYCLE OF BLAST CELLS INVOLVED IN SECONDARY ANTIBODY RESPONSE.参与二次抗体应答的母细胞的细胞周期。
J Immunol. 1964 Oct;93:696-700.
引用本文的文献
1
Biochemical and biophysical characterization of humanized IgG1 produced in Pichia pastoris.毕赤酵母表达的人源化 IgG1 的生化和生物物理特性分析。
MAbs. 2011 Sep-Oct;3(5):453-60. doi: 10.4161/mabs.3.5.16891. Epub 2011 Sep 1.
2
3
Normal induction and maintenance of tolerance in (NZBxNZW) F1 mice.（新西兰黑鼠×新西兰白鼠）F1代小鼠中耐受性的正常诱导与维持。
Clin Exp Immunol. 1969 Sep;5(3):265-72.
4
Further studies on the effect of anti-lymphocytic antibody on humoral antibody formation.抗淋巴细胞抗体对体液抗体形成影响的进一步研究。
Clin Exp Immunol. 1968 Nov;3(9):963-72.
5
The immunosuppressive properties of sub-fractions of antilymphocytic IgG of equine origin.马源抗淋巴细胞IgG亚组分的免疫抑制特性。
Immunology. 1971 Aug;21(2):247-57.
6
7
8
Some factors influencing the ability of anti-lymphocytic antibody to suppress humoral antibody formation.一些影响抗淋巴细胞抗体抑制体液抗体形成能力的因素。
Clin Exp Immunol. 1967 Nov;2(6):685-90.
9
Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).T淋巴细胞对丝裂原反应的增强作用。II. 增强介质的细胞来源。
J Exp Med. 1972 Jul 1;136(1):143-55. doi: 10.1084/jem.136.1.143.
本文引用的文献
1
A theory of delayed hypersensitivity.一种迟发型超敏反应理论。
Science. 1962 Jun 22;136(3521):1032-9. doi: 10.1126/science.136.3521.1032.
2
Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
3
PHAGOCYTOSIS OF THE ANTIGEN, A CRUCIAL STEP IN THE INDUCTION OF THE PRIMARY RESPONSE.抗原的吞噬作用，是初次免疫应答诱导过程中的关键步骤。
Proc Natl Acad Sci U S A. 1965 Jan;53(1):20-3. doi: 10.1073/pnas.53.1.20.
4
[STIMULATION OF THE PHAGOCYTIC ACTIVITY OF THE RETICULOENDOTHELIAL SYSTEM BY CORYNEBACTERIUM PARVUM].[短小棒状杆菌对网状内皮系统吞噬活性的刺激作用]
J Reticuloendothel Soc. 1964 Jan;1:77-96.
5
[ADJUVANT PROPERTIES OF CORYNEBACTERIUM PARVUM ON ANTIBODY PRODUCTION AND ON THE INDUCTION OF DELAYED HYPERSENSITIVITY TOWARD CONJUGATED PROTEINS].短小棒状杆菌对抗体产生及对结合蛋白迟发型超敏反应诱导的佐剂特性
Ann Inst Pasteur (Paris). 1964 May;106:771-7.
6
TOLERANCE TO A PROTEIN ANTIGEN IN ADULT MICE AND THE EFFECT OF NONSPECIFIC FACTORS.成年小鼠对蛋白质抗原的耐受性及非特异性因素的影响
J Immunol. 1963 Dec;91:833-9.
7
8
The affinity of the reticulo-endothelial system for various modified serum proteins.网状内皮系统对各种修饰血清蛋白的亲和力。
Br J Exp Pathol. 1960 Apr;41(2):190-7.
9
A quantitative immunochemical measure of the primary interaction between I BSA and antibody.一种对牛血清白蛋白（BSA）与抗体之间主要相互作用的定量免疫化学测定方法。
J Infect Dis. 1958 Nov-Dec;103(3):239-62. doi: 10.1093/infdis/103.3.239.
10
Genetically controlled specific immunological unresponsiveness.基因控制的特异性免疫无反应性。
Immunology. 1966 Nov;11(5):511-3.
Zotero 插件