Cohen A M, Shabtai F, Lewinski U, Klein B, Djaldetti M
Clin Genet. 1979 Sep;16(3):178-82. doi: 10.1111/j.1399-0004.1979.tb00988.x.
Paroxysmal nocturnal hemoglobinuria (PNH) is considered to be a clonal disorder, although most investigations have failed to show chromosomal abnormalities. The present patient suffered from PNH and exhibited in bone marrow cells two abnormal clones with 47 chromosomes in addition to cells with 46 chromosomes. One clone showed trisomy 9, a finding previously reported in leukemias and myeloproliferative disorders. Thus, PNH seems to be a clonal myeloproliferative disease.
阵发性睡眠性血红蛋白尿（PNH）被认为是一种克隆性疾病，尽管大多数研究未能显示出染色体异常。本患者患有PNH，其骨髓细胞中除了有46条染色体的细胞外，还出现了两个含有47条染色体的异常克隆。其中一个克隆显示9号染色体三体，这一发现先前在白血病和骨髓增殖性疾病中已有报道。因此，PNH似乎是一种克隆性骨髓增殖性疾病。
