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Paroxysmal nocturnal hemoglobinuria (PNH) as a clonal disorder.

作者信息

Hartmann R C, Arnold A B

出版信息

Annu Rev Med. 1977;28:187-94. doi: 10.1146/annurev.me.28.020177.001155.

DOI:10.1146/annurev.me.28.020177.001155
PMID:324358
Abstract
  1. Clonal theories of disease, particularly progressive clonal growth and selection in tumorogenesis, were briefly cited. 2. Evidence for the clonal nature of PNH was presented. Correlation of red cell hemolysis with (a) G-6-PD type in two female G-6-PD mosaics with PNH and with (b) erythrocyte acetylcholinesterase deficiency, provides strong evidence for the clonal theory of PNH. 3. Possible pitfalls in defining "hidden PNH clones" in other diseases by the use of PNH hemolytic tests were discussed. 4. The potential of PNH as a study model for clonal evolution in human disease was emphasized.
摘要

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2
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引用本文的文献

1
Paroxysmal Nocturnal Hemoglobinuria with Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report and Review of the Literature.阵发性夜间血红蛋白尿合并葡萄糖-6-磷酸脱氢酶缺乏症：一例报告及文献复习
Case Rep Oncol. 2019 Nov 1;12(3):838-844. doi: 10.1159/000503817. eCollection 2019 Sep-Dec.
2
Complement-mediated haemolysis and the role of blood transfusion in paroxysmal nocturnal haemoglobinuria.补体介导的溶血及输血在阵发性夜间血红蛋白尿中的作用。
Blood Transfus. 2015 Jul;13(3):363-9. doi: 10.2450/2015.0249-14. Epub 2015 Feb 2.
3
Lymphocyte zinc metabolism in disease : Paroxysmal noctural hemoglobinuria.
疾病中的淋巴细胞锌代谢：阵发性夜间血红蛋白尿症。
Biol Trace Elem Res. 1983 Feb;5(1):47-53. doi: 10.1007/BF02916926.
4
Abnormality of glycophorin-alpha on paroxysmal nocturnal hemoglobinuria erythrocytes.阵发性夜间血红蛋白尿症红细胞上血型糖蛋白α的异常。
J Clin Invest. 1984 Apr;73(4):1130-43. doi: 10.1172/JCI111299.