Tiburskaja N A, Sergiev P G, Vrublevskaja O S
Bull World Health Organ. 1968;38(3):447-57.
The course of induced tertian malaria has been studied in patients in psychoneurological hospitals in Moscow over a long period. Various strains of P. vivax were used to infect patients; the sporozoites were transmitted by Anopheles maculipennis atroparvus bred under laboratory conditions. There are marked differences between the dates of onset of relapses, reckoned from the primary manifestations of the disease, in patients developing malaria after long and short incubation periods. P. vivax strains which have a short incubation period are characterized by producing in patients a series of relapses following a long latent period; strains with a long incubation period are characterized by the occurrence of relapses during the first 3 months after the end of the primary series of attacks. However, some P. vivax strains give rise to both types of relapse, depending on the incubation period. In any event, the duration of the disease does not, as a rule, exceed 2 years, including the incubation period. The number of mosquitos (and hence the number of sporozoites) used to infect a patient does not have any noticeable effect on the number and frequency of relapses. In short-incubation tertian malaria, the use of quinocide during the period of treatment of the primary manifestations greatly reduced the number of relapses; in long-incubation tertian malaria similarly treated with quinocide, no relapses occurred.
长期以来，莫斯科精神神经科医院的患者一直在接受间日疟诱导病程的研究。使用各种间日疟原虫菌株感染患者；子孢子由在实验室条件下培育的微小按蚊传播。从疾病的主要表现算起，潜伏期长短不同的疟疾患者复发开始日期存在显著差异。潜伏期短的间日疟原虫菌株的特点是，在患者体内经过很长的潜伏期后会出现一系列复发；潜伏期长的菌株的特点是，在初次发作系列结束后的头3个月内出现复发。然而，一些间日疟原虫菌株会根据潜伏期产生两种类型的复发。无论如何，该病的病程通常不超过2年，包括潜伏期。用于感染患者的蚊子数量（进而子孢子数量）对复发的数量和频率没有任何明显影响。在短潜伏期的间日疟中，在初次表现治疗期间使用奎诺杀星可大大减少复发次数；在同样用奎诺杀星治疗的长潜伏期间日疟中，未发生复发。
