人体镉代谢模型。
Metabolic model for cadmium in man.
作者信息
Nordberg G F, Kjellström T
出版信息
Environ Health Perspect. 1979 Feb;28:211-7. doi: 10.1289/ehp.7928211.
Abstract
A metabolic model for cadmium has been formulated in terms of a flow scheme for cadmium among eight body compartments. The mathematical description of the flow of cadmium between compartments consits of a number of differential equations, and the accumulation of cadmium may thus be calculated. Coeffcients for the flow of cadmium were estimated from empirical data both from animals and man. The modelling serves two main purposes: it provides a means of using present knowledge about metabolism in order to calculate expected accumulation in critical organs and other tissues and body fluids at certain intake levels and it makes it possible to define deficiencies in our present knowledge about metabolism. Data recently collected, partly as a result of considerations related to the model, have confirmed the assumptions of a very long biological half-time in other tissues and the small excretion of cadmium via bile.
摘要
已根据镉在八个身体隔室之间的流动方案制定了镉的代谢模型。隔室之间镉流动的数学描述由多个微分方程组成，因此可以计算镉的积累量。镉流动系数是根据动物和人类的经验数据估算得出的。该模型有两个主要目的：它提供了一种利用现有代谢知识的方法，以便计算在特定摄入水平下关键器官、其他组织和体液中的预期积累量，并且使我们能够明确目前代谢知识中的不足之处。最近收集的数据，部分是由于与该模型相关的考虑因素，证实了其他组织中生物半衰期非常长以及镉通过胆汁排泄量小的假设。
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本文引用的文献
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Distribution of metallothionein-bound cadmium and cadmium chloride in mice: preliminary studies.
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Increased dietary cadmium absorption in mice and human subjects with iron deficiency.缺铁的小鼠和人类受试者对膳食镉的吸收增加。
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Pancreatic and biliary excretion of cadmium in the rat.
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