Gemmell M A, Soulsby E J
Bull World Health Organ. 1968;39(1):45-55.
An assessment is made of the present state of knowledge on acquired immune responses developed by the intermediate and definitive hosts to tapeworm infections. From this evaluation, some gaps in knowledge and some of the problems associated with the development of practical immunization techniques are described. The principal conclusion reached is that absolute resistance to the larval stage can be acquired and resistance to a number of cestode species can be artificially induced in a number of hosts. Thus, research directed towards isolation and characterization of the functional antigens may lead to the development of vaccines for use in public health programmes, such as for the control of echinococcosis, as well as for improving the present status of meat hygiene in regions where cysticercosis, for example, exists.
本文对中间宿主和终宿主针对绦虫感染所产生的获得性免疫反应的现有知识状况进行了评估。基于该评估，阐述了一些知识空白以及与实用免疫技术开发相关的一些问题。得出的主要结论是，在许多宿主中可以获得对幼虫阶段的绝对抗性，并且可以人工诱导对多种绦虫物种的抗性。因此，针对功能性抗原的分离和表征开展的研究可能会促成用于公共卫生项目的疫苗的开发，比如用于控制棘球蚴病，以及改善例如存在囊尾蚴病地区的肉类卫生现状。
