Markowitz H, Person D A, Gitnick G L, Ritts R E
Science. 1969 Jan 31;163(3866):476. doi: 10.1126/science.163.3866.476.
Two strains of mice (C-57 B] and DBA) were given skin allografts from Swiss ICR/HA mice and were treated with varying doses of concanavalin A; the dosage ranged from only two injections of 25 micrograms during the experiment to daily doses of 1000 micrograms intraperitoneally. Immullosuppression was present at all dosages, the most prolonged and consistent effect being observed at 300 micrograms per day. Grafts survived for 14 to 21 days at this dosage compared to 4 to 9 days for controls.
给两种品系的小鼠（C-57 B]和DBA）移植来自瑞士ICR/HA小鼠的皮肤异体移植物，并给予不同剂量的伴刀豆球蛋白A进行治疗；剂量范围从实验期间仅两次注射25微克到每天腹腔注射1000微克。所有剂量均出现免疫抑制，每天300微克时观察到的效果最为持久和稳定。在此剂量下，移植物存活14至21天，而对照组为4至9天。
