干扰素对小鼠迟发型超敏反应的抑制作用。
Inhibition by interferon of delayed-type hypersensitivity in the mouse.
作者信息
De Maeyer E, De Maeyer-Guignard J, Vandeputte M
出版信息
Proc Natl Acad Sci U S A. 1975 May;72(5):1753-7. doi: 10.1073/pnas.72.5.1753.
Abstract
The effect of interferon on delayed-type by persensitivity to picryl chloride and sheep erythrocytes was examined in the mouse. When administered to sensitized animals on the day before or the day of challenge, tissue culture interferon inhibited both the ear swelling induced by pieryl chloride and footpad swelling induced by sheep erythrocytes. Newcastle disease virus, when injected into sensitized If-1l or If-1h congenic mice a few hours before challenge, caused an inhibition of delayed-type hypersensitivity which could be related to the amount of serum interferon induced by the virus. These results indicate that interferon production may represent one of the factors responsible for the depression of cell-mediated immune reactions during virus infection.
摘要
在小鼠中研究了干扰素对二硝基氯苯和绵羊红细胞迟发型超敏反应的影响。当在攻击前一天或攻击当天给予致敏动物时，组织培养干扰素可抑制二硝基氯苯诱导的耳部肿胀和绵羊红细胞诱导的足垫肿胀。新城疫病毒在攻击前几小时注射到致敏的If-1l或If-1h同源小鼠中，可导致迟发型超敏反应受到抑制，这可能与病毒诱导的血清干扰素量有关。这些结果表明，干扰素的产生可能是病毒感染期间细胞介导免疫反应受抑制的因素之一。
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