Sporn M B, Newton D L
Fed Proc. 1979 Oct;38(11):2528-34.
The importance of retinoids for chemoprevention of cancer has received further emphasis with the finding that retinoids can suppress in vitro expression of the malignant phenotype, whether it be caused by chemical carcinogens, radiation, or viral transforming factors. Retinoids have been found to be potent inhibitors of the tumor-promoting effects of phorbol esters. Further advances in the chemistry of synthetic retinoids have led to the development of new agents that show less toxicity and better targeting to specific organ sites than natural retinoids. Synthetic retinoids have been particularly useful for prevention of bladder and breast cancer in experimental animals.
随着类视黄醇能够抑制恶性表型的体外表达这一发现，无论是由化学致癌物、辐射还是病毒转化因子引起的，类视黄醇对癌症化学预防的重要性得到了进一步强调。已发现类视黄醇是佛波酯肿瘤促进作用的有效抑制剂。合成类视黄醇化学的进一步进展导致了新药物的开发，这些新药物比天然类视黄醇显示出更低的毒性和对特定器官部位更好的靶向性。合成类视黄醇在实验动物中对预防膀胱癌和乳腺癌特别有用。
