Tweed J A, Mason B, Sleigh R
J Int Med Res. 1979;7(4):324-7. doi: 10.1177/030006057900700412.
A large scale study in general practice was set up to investigate the effects of transferring hypertensive patients from treatment with usually less than 1 g daily of methyldopa to atenolol ('Tenormin') 100 mg daily. The results demonstrate an improvement in blood pressure control with atenolol treatment and a reduction in the incidence of side-effects. The simple dosage regime, combined with proven effectiveness and a relative lack of side-effects makes atenolol a useful treatment for the hypertensive patient.
开展了一项全科医疗的大规模研究,以调查将高血压患者从通常每日服用少于1克甲基多巴的治疗方案转换为每日服用100毫克阿替洛尔(“天诺敏”)的效果。结果表明,阿替洛尔治疗可改善血压控制情况,并降低副作用发生率。简单的给药方案,加上已证实的有效性和相对较少的副作用,使阿替洛尔成为高血压患者的一种有效治疗药物。