Konturek S J, Kwiecień N, Obtułowicz W, Mikoś E, Sito E, Oleksy J
Gut. 1978 Oct;19(10):859-64. doi: 10.1136/gut.19.10.859.
The ability of an amino acid mixture given intraduodenally or intravenously to stimulate gastric secretion is compared in healthy subjects and in duodenal ulcer patients. Graded amounts of amino acids by both routes produced a similar increase in acid output in healthy subjects, reaching about 30% of the maximal response to pentagastrin. Serum gastrin concentrations remained virtually unchanged but serum alpha amino acid nitrogen levels were about twice as high with intravenous as with intraduodenal administration. Intravenously administered amino acids produced a significantly higher acid output in patients with duodenal ulcer than in healthy subjects, but did not produce a significant increase in gastric acid or pepsin secretion when combined with a pentagastrin infusion as compared with pentagastrin alone. Cimetidine (2 mg/kg/h) added to intravenous amino acid infusions caused almost complete suppression of acid secretion. This study indicates that amino acids are capable of stimulating gastric secretion after intraduodenal and after intravenous administration. The response to the latter is significantly higher in patients with duodenal ulcer than in healthy subjects, does not appear to involve gastrin release, is not affected by pentagastrin, and is strongly suppressed by histamine H2-blocker.
在健康受试者和十二指肠溃疡患者中，比较十二指肠内或静脉内给予氨基酸混合物刺激胃液分泌的能力。通过两种途径给予不同剂量的氨基酸，在健康受试者中产生了相似的胃酸分泌增加，达到对五肽胃泌素最大反应的约30%。血清胃泌素浓度几乎保持不变，但静脉给药时血清α-氨基酸氮水平约为十二指肠内给药时的两倍。静脉内给予氨基酸在十二指肠溃疡患者中产生的胃酸分泌明显高于健康受试者，但与单独使用五肽胃泌素相比，与五肽胃泌素输注联合使用时并未显著增加胃酸或胃蛋白酶分泌。将西咪替丁（2mg/kg/h）添加到静脉内氨基酸输注中几乎完全抑制了胃酸分泌。本研究表明，氨基酸在十二指肠内给药和静脉内给药后均能刺激胃液分泌。十二指肠溃疡患者对静脉内给药的反应明显高于健康受试者，似乎不涉及胃泌素释放，不受五肽胃泌素影响，并被组胺H2受体阻滞剂强烈抑制。
