Cobden I, Rothwell J, Axon A T
Gut. 1979 Aug;20(8):716-21. doi: 10.1136/gut.20.8.716.
Passive intestinal permeability has been investigated in rats infected by the nematode, Nippostrongylus brasiliensis, by the simultaneous administration of two probe molecules. Experiments using a closed intestinal loop show that there is a significantly increased absorption of lactulose and decreased absorption of mannitol in rats at the 10th to 11th day of infection. Experiments using serial oral administration techniques show that these changes start during the second week of the infection with a return towards normal values by the end of the third week. The results are similar to those found in human coeliac disease and add weight to previous studies which have stressed the similarity in the two disease processes.
通过同时给予两种探针分子，研究了感染巴西日圆线虫的大鼠的被动肠通透性。使用封闭肠袢的实验表明，在感染第10至11天，大鼠体内乳果糖的吸收显著增加，而甘露醇的吸收减少。使用连续口服给药技术的实验表明，这些变化在感染的第二周开始出现，并在第三周结束时恢复到正常值。这些结果与人类乳糜泻的结果相似，进一步支持了先前强调这两种疾病过程相似性的研究。
