McGovern V J, Shaw H M, Milton G W, Farago G A
Histopathology. 1979 Sep;3(5):385-93. doi: 10.1111/j.1365-2559.1979.tb03020.x.
A review of 694 patients with localized cutaneous malignant melanoma (clinical stage I) revealed that three histological features of the primary lesion had no effect of their own on survival rate but derived their prognostic significance only because of their close correlation with tumour thickness. Primary lesions of superficial spreading histogenetic type, or of low mitotic activity or showing evidence of partial regression appeared to have a more favourable prognosis than lesions of nodular histogenetic type or of high mitotic activity or showing no regression. However, the former three histological features were predominant in thin lesions which had a better prognosis than thicker lesions. It was concluded that these features exerted only an indirect effect upon survival, tumour thickness being the most important prognostic determinant.
对694例局限性皮肤恶性黑色素瘤（临床I期）患者的回顾性研究表明，原发性病变的三个组织学特征本身对生存率没有影响，其预后意义仅源于它们与肿瘤厚度的密切相关性。浅表扩散组织发生类型、有丝分裂活性低或有部分消退迹象的原发性病变，其预后似乎比结节性组织发生类型、有丝分裂活性高或无消退迹象的病变更有利。然而，前三个组织学特征在薄病变中占主导，薄病变的预后比厚病变更好。得出的结论是，这些特征仅对生存率产生间接影响，肿瘤厚度是最重要的预后决定因素。
