人类心脏移植中的乳酸脱氢酶同工酶

Lactate dehydrogenase isozymes in human cardiac transplantation.

作者信息

Nora J J, Cooley D A, Johnson B L, Watson S C, Milam J D

出版信息

Science. 1969 May 30;164(3883):1079-80. doi: 10.1126/science.164.3883.1079.

DOI:10.1126/science.164.3883.1079

Abstract

Lactate dehydrogenase (LDH) isozyme activities have been followed in 17 human cardiac allografts. A pattern of abnormality associated with cardiac rejection during the first month after operation has been determined: (i) LDH-1 activity is greater than LDH-2 activity; (ii) LDH-1 activity is greater than 35 percent of total LDH activity; and (iii) LDH-1 activity is greater than 100 international units. The LDH-1 abnormality helps to meet the need for an index of cardiac rejection during the early weeks after operation when the electro-cardiogram is least reliable.

摘要

对17例人体心脏同种异体移植患者的乳酸脱氢酶（LDH）同工酶活性进行了跟踪研究。已确定了术后第一个月与心脏排斥反应相关的异常模式：（i）LDH-1活性大于LDH-2活性；（ii）LDH-1活性大于总LDH活性的35%；（iii）LDH-1活性大于100国际单位。当心电图最不可靠时，LDH-1异常有助于满足术后早期心脏排斥反应指标的需求。