暗修复合成的饱和：链断裂的积累。
Saturation of dark repair synthesis: accumulation of strand breaks.
作者信息
Achey P, Billen D
出版信息
Biophys J. 1969 May;9(5):647-53. doi: 10.1016/S0006-3495(69)86409-X.
Abstract
Reversal of ultraviolet light damage to DNA by the dark repair system is limited. Experiments utilizing density and radioactive labels demonstrated that repair synthesis is not proportional to dose at doses above 200 ergs/mm(2). In addition, the number of residual excision induced gaps in Escherichia coli B/r hcr(+) DNA increases with higher UV doses. The extent of repair is apparently limited by saturation of the repair synthesis step.
摘要
暗修复系统对紫外线造成的DNA损伤的修复作用是有限的。利用密度标记和放射性标记进行的实验表明，当剂量超过200尔格/平方毫米时，修复合成与剂量不成正比。此外，在大肠杆菌B/r hcr(+) DNA中，残留的切除诱导缺口数量会随着紫外线剂量的增加而增多。修复程度显然受到修复合成步骤饱和的限制。
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