从N-羟基脲诱导的死亡中恢复。
Recovery from N-hydroxyurethan-induced death.
作者信息
Mullinix K P, Rosenkranz H S
出版信息
J Bacteriol. 1971 Feb;105(2):565-72. doi: 10.1128/jb.105.2.565-572.1971.
Abstract
Bacteria (Escherichia coli) can recover from the lethal action of N-hydroxyurethan when they are incubated in drug-free liquid medium. This recovery, which is dependent upon energy metabolism, does not occur on solid medium. Recovery is accompanied by repair of the cellular deoxyribonucleic acid (DNA). A bacterial mutant deficient in DNA polymerase was extremely sensitive to the lethal action of hydroxyurethan. Data are presented which support the concept that DNA replication and DNA repair are mediated by different enzymes and that only the former process is inhibited by hydroxyurea.
摘要
细菌（大肠杆菌）在不含药物的液体培养基中培养时，能够从N - 羟基脲的致死作用中恢复。这种依赖于能量代谢的恢复在固体培养基上不会发生。恢复过程伴随着细胞脱氧核糖核酸（DNA）的修复。一种缺乏DNA聚合酶的细菌突变体对羟基脲的致死作用极为敏感。所呈现的数据支持这样的概念，即DNA复制和DNA修复由不同的酶介导，并且只有前者的过程会被羟基脲抑制。
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本文引用的文献
1
On the Relation between Assimilation and Respiration in Suspensions and in Cultures of Escherichia coli.关于大肠杆菌悬浮液和培养物中同化作用与呼吸作用的关系
J Bacteriol. 1939 May;37(5):523-40. doi: 10.1128/jb.37.5.523-540.1939.
2
The use of arsenate in the analysis of energy relations amongst synthetic reactions.砷酸盐在合成反应能量关系分析中的应用。
Arch Biochem. 1950 Nov;29(1):85-100.
3
PHENETHYL ALCOHOL. I. EFFECT ON MACROMOLECULAR SYNTHESIS OF ESCHERICHIA COLI.苯乙醇。一、对大肠杆菌大分子合成的影响。
J Bacteriol. 1965 May;89(5):1354-69. doi: 10.1128/jb.89.5.1354-1369.1965.
4
HYDROXYUREA: A SPECIFIC INHIBITOR OF DEOXYRIBONUCLEIC ACID SYNTHESIS.羟基脲：一种脱氧核糖核酸合成的特异性抑制剂。
Biochim Biophys Acta. 1965 Jan 11;95:181-3. doi: 10.1016/0005-2787(65)90225-x.
5
PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.嘌呤霉素对蛋白质合成的抑制作用：嘌呤霉素掺入肽链的过程。
Proc Natl Acad Sci U S A. 1964 Apr;51(4):585-92. doi: 10.1073/pnas.51.4.585.
6
THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM.胸腺嘧啶二聚体从DNA中的消失：一种纠错机制。
Proc Natl Acad Sci U S A. 1964 Feb;51(2):226-31. doi: 10.1073/pnas.51.2.226.
7
The assimilation of amino-acids by bacteria. XV. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus.细菌对氨基酸的同化作用。十五。抗生素对金黄色葡萄球菌核酸和蛋白质合成的作用。
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