镉离子和锌离子对豚鼠离体回肠标本的解痉作用。
Spasmolytic effects of cadmium and zinc ions upon the guinea-pig isolated ileum preparation.
作者信息
Schnieden H, Small R C
出版信息
Br J Pharmacol. 1971 Mar;41(3):488-99. doi: 10.1111/j.1476-5381.1971.tb08046.x.
Abstract
- An investigation has been made of the effects of cadmium and zinc ions upon the contractile response of the guinea-pig isolated ileum to methacholine, histamine, potassium ion and a.c. field stimulation. The metal ions depress the response to all of these agents.2. Radioisotope studies showed that cadmium and zinc ions have very much larger apparent volumes of distribution than sorbitol, both within whole ileum and within strips of the longitudinal smooth muscle layer. The results of these studies were indicative of surface binding and/or intracellular accumulation of these ions.3. It is suggested that cadmium and zinc ions directly depress smooth muscle contractility in a non-specific manner. This action may result from their binding to or accumulation within the muscle cells.
摘要
已对镉离子和锌离子对豚鼠离体回肠对乙酰甲胆碱、组胺、钾离子及交流电刺激的收缩反应的影响进行了研究。金属离子会抑制对所有这些药剂的反应。
放射性同位素研究表明，在整个回肠及纵向平滑肌层条带内，镉离子和锌离子的表观分布容积比山梨醇大得多。这些研究结果表明这些离子存在表面结合和/或细胞内蓄积现象。
有人提出，镉离子和锌离子以非特异性方式直接抑制平滑肌收缩力。这种作用可能是由于它们与肌肉细胞结合或在肌肉细胞内蓄积所致。
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