噬菌体T4 DNA复制过程中发生的事件。
Events occurring during the replication of bacteriophage T4 DNA.
作者信息
Scotti P D
出版信息
Proc Natl Acad Sci U S A. 1969 Apr;62(4):1093-9. doi: 10.1073/pnas.62.4.1093.
Abstract
Ten temperature-sensitive mutants of T4D have been examined to find the times in the lytic cycle at which a shift to a restrictive temperature no longer exerts a lethal effect. Nine of these mutants play a role in phage DNA synthesis. The results of these experiments suggest that the products of three of the genes tested-genes 42, 44, and 45-have control or complexing functions in addition to any enzymatic ones. The data also indicate that the products of genes 30 and 41 may act cooperatively. The properties of mutants of gene 43 (DNA polymerase) and gene 56 (dCTP-dUTPase) suggest that the production of a certain length of concatameric DNA is necessary before viable phage can be produced.
摘要
已对T4D的十个温度敏感突变体进行了检测，以确定在裂解周期中何时转移到限制温度不再产生致死效应。这些突变体中有九个在噬菌体DNA合成中起作用。这些实验结果表明，所测试的三个基因（基因42、44和45）的产物除了具有任何酶促功能外，还具有控制或复合功能。数据还表明，基因30和41的产物可能协同作用。基因43（DNA聚合酶）和基因56（dCTP-dUTPase）突变体的特性表明，在产生有活力的噬菌体之前，产生一定长度的串联DNA是必要的。
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Proc Natl Acad Sci U S A. 1967 Aug;58(2):665-72. doi: 10.1073/pnas.58.2.665.
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