Tosi P, Cintorino M, Luzi P, Lungarella G
Boll Soc Ital Biol Sper. 1978 Oct 15;54(19):1887-92.
Morphometrical analysis of lymphoid organs has been performed 30 days after bilateral ovariectomy in Wistar rats. The percentage of thymus medullary area and lymph node cortical area (containing numerous large germinal centers) have been found increased. No significant changes there were in paracortical areas. The enlarged thymus medullary area, showing small lymphocytes in lymphatic vessels, could be correlated with the hyperfunction of "helper" T-lymphocytes. These findings indicate that morphological signs of increased antibody mediated immunity of the lymphoid organs appear in ovariectomized rats.
对Wistar大鼠双侧卵巢切除术后30天的淋巴器官进行了形态计量学分析。发现胸腺髓质区和淋巴结皮质区（含有大量大生发中心）的百分比增加。副皮质区没有明显变化。扩大的胸腺髓质区可见淋巴管内有小淋巴细胞，这可能与“辅助性”T淋巴细胞功能亢进有关。这些发现表明，去卵巢大鼠的淋巴器官出现了抗体介导免疫增强的形态学迹象。
