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Modulation of hydroxymethylglutaryl-CoA reductase activity, reductase kinase activity, and cholesterol synthesis in rat hepatocytes in response to insulin and glucagon.

作者信息

Ingebritsen T S, Geelen M J, Parker R A, Evenson K J, Gibson D M

出版信息

J Biol Chem. 1979 Oct 25;254(20):9986-9.

PMID:489617
Abstract
摘要

相似文献

1
Modulation of hydroxymethylglutaryl-CoA reductase activity, reductase kinase activity, and cholesterol synthesis in rat hepatocytes in response to insulin and glucagon.大鼠肝细胞中羟甲基戊二酰辅酶A还原酶活性、还原酶激酶活性及胆固醇合成对胰岛素和胰高血糖素的响应调节
J Biol Chem. 1979 Oct 25;254(20):9986-9.
2
Influence of insulin and glucagon on the cholesterol synthesis in rat liver in vivo. Evidence against a rate limiting function of the HMG-coenzyme A reductase.
Helv Chim Acta. 1977 Sep 21;60(6):1967-8. doi: 10.1002/hlca.19770600617.
3
The effect of glucagon, norepinephrine, and dibutyryl cyclic AMP on cholesterol efflux and on the activity of 3-hydroxy-3-methylglutaryl CoA reductase in rat hepatocytes.胰高血糖素、去甲肾上腺素和二丁酰环磷酸腺苷对大鼠肝细胞胆固醇外流及3-羟基-3-甲基戊二酰辅酶A还原酶活性的影响。
J Lipid Res. 1979 Jan;20(1):2-7.
4
Diurnal changes in the rate of cholesterogenesis in hepatocytes from fed and starved rats: effects of precursors and pancreatic hormones in vitro.喂食和饥饿大鼠肝细胞中胆固醇生成速率的昼夜变化：体外前体和胰腺激素的影响
Arch Biochem Biophys. 1985 Apr;238(1):135-45. doi: 10.1016/0003-9861(85)90149-3.
5
Short-term regulation of hydroxymethylglutaryl coenzyme A reductase by reversible phosphorylation: modulation of reductase phosphatase in rat hepatocytes.通过可逆磷酸化对羟甲基戊二酰辅酶A还原酶进行短期调节：大鼠肝细胞中还原酶磷酸酶的调节作用
Adv Enzyme Regul. 1982;20:263-83. doi: 10.1016/0065-2571(82)90020-6.
6
Regulation of liver 3-hydroxy-3-methylglutaryl-CoA reductase.肝脏3-羟基-3-甲基戊二酰辅酶A还原酶的调节
Curr Top Cell Regul. 1981;20:139-84. doi: 10.1016/b978-0-12-152820-1.50008-0.
7
Rapid modulation of rat hepatocyte HMG-CoA reductase activity by cyclic AMP or cyclic GMP.环磷酸腺苷（cAMP）或环磷酸鸟苷（cGMP）对大鼠肝细胞HMG-CoA还原酶活性的快速调节
Physiol Chem Phys Med NMR. 1985;17(1):35-40.
8
Hormonal control of cholesterogenesis and related enzymes in isolated rat hepatocytes during pre- and postnatal development.出生前和出生后发育期间，离体大鼠肝细胞中胆固醇生物合成及相关酶的激素调控。
J Cell Physiol. 1985 Dec;125(3):507-11. doi: 10.1002/jcp.1041250321.
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A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.
FEBS Lett. 1987 Nov 2;223(2):217-22. doi: 10.1016/0014-5793(87)80292-2.
10
In vitro and in vivo phosphorylation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase and its modulation by glucagon.大鼠肝脏3-羟基-3-甲基戊二酰辅酶A还原酶的体外和体内磷酸化及其受胰高血糖素的调节
J Biol Chem. 1980 Sep 25;255(18):8541-5.

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Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.仓鼠3-羟基-3-甲基戊二酰辅酶A还原酶丝氨酸-871位点的替换可阻止AMP激活的蛋白激酶的磷酸化作用，并阻断ATP耗竭诱导的固醇合成抑制。
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9261-5. doi: 10.1073/pnas.90.20.9261.
5
The role of substrate supply in the regulation of cholesterol biosynthesis in rat hepatocytes.底物供应在大鼠肝细胞胆固醇生物合成调节中的作用。
Biochem J. 1983 Mar 15;210(3):625-32. doi: 10.1042/bj2100625.
6
In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone.甲羟戊酸内酯对大鼠肝脏3-羟基-3-甲基戊二酰辅酶A还原酶、还原酶激酶及还原酶激酶激酶的体内调节作用
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7293-7. doi: 10.1073/pnas.81.23.7293.
7
Regulation of three key enzymes in cholesterol metabolism by phosphorylation/dephosphorylation.通过磷酸化/去磷酸化对胆固醇代谢中三种关键酶的调控。
Proc Natl Acad Sci U S A. 1983 May;80(9):2477-80. doi: 10.1073/pnas.80.9.2477.
8
Overproduction of a Mr 92,000 protomer of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in compactin-resistant C100 cells.在对美伐他汀耐药的C100细胞中，3-羟基-3-甲基戊二酰辅酶A还原酶的一种分子量为92,000的亚基过度产生。
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1516-20. doi: 10.1073/pnas.80.6.1516.
9
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.3-羟基-3-甲基戊二酰辅酶A还原酶的调节
Mol Cell Biochem. 1983;53-54(1-2):299-306. doi: 10.1007/BF00225261.
10
Stimulation of bile acid synthesis by dibutyryl cyclic AMP in isolated rat hepatocytes.二丁酰环磷腺苷对离体大鼠肝细胞胆汁酸合成的刺激作用。
Lipids. 1983 Jul;18(7):443-7. doi: 10.1007/BF02535783.