Bradlow H L, Schwartz M K, Fleisher M, Nisselbaum J S, Boyar R, O'Connor J, Fukushima D K
J Clin Endocrinol Metab. 1979 Nov;49(5):778-82. doi: 10.1210/jcem-49-5-778.
The concentration of some immunoreactive peptide hormones in breast cyst fluid and serum from a series of patients with cystic breast disease were compared. The concentrations of the two pituitary gonadotropins, LH and FSH, were consistently higher in serum than in cyst fluid, confirming earlier more limited observations. The mean PRL concentration, on the other hand, was elevated in cyst fluid though the variability was great. The cyst fluid serum ratio of hCG was elevated in the patient group as a whole. However, the results suggested the presence of two subpopulations; group I, in which the cyst fluid and serum hCG levels were essentially indistinguishable and in the range found in normal serum, and group II, in which the cyst fluid hCG concentration was consistently greater than the normal serum range. Analysis of hormone concentrations in multiple cysts aspirated at the same time showed a remarkable degree of agreement in the cyst hormone levels in most of the patients. The greatest variability in the levels was seen with hCG, were a small numer of subjects showed a very large spread in the values.
对一系列乳腺囊性疾病患者的乳腺囊肿液和血清中某些免疫反应性肽类激素的浓度进行了比较。两种垂体促性腺激素LH和FSH的浓度在血清中始终高于囊肿液，这证实了早期更有限的观察结果。另一方面，尽管变异性很大，但囊肿液中的PRL平均浓度升高。整个患者组中hCG的囊肿液与血清比值升高。然而，结果提示存在两个亚组；第一组，囊肿液和血清hCG水平基本无差异，且在正常血清范围内；第二组，囊肿液hCG浓度始终高于正常血清范围。对同一时间抽取的多个囊肿中的激素浓度进行分析显示，大多数患者囊肿中的激素水平具有显著的一致性。hCG水平的变异性最大，少数受试者的值分布范围非常大。
