Sartorius O W
Research Dept., Santa Barbara Breast Cancer Institute, CA 93108, USA.
Breast Cancer Res Treat. 1995 Sep;35(3):255-66. doi: 10.1007/BF00665977.
The ratio of potassium to sodium concentrations in breast fluids has led other investigators to the subclassification of cysts into two types: 1) apocrine (secretory) cysts with high potassium and low sodium, and 2) attenuated (flattened) cell cysts with low potassium and high sodium content. Apocrine cells are thought by some to actively secrete potassium. Cell typing is considered important as apocrine cysts are more likely to be bilateral, multiple, recurrent, and serve as markers for epithelial cell atypia. A retrospective study of the biochemical analyses of 58 cyst fluids and 28 duct secretions obtained by nipple aspiration was conducted. Potassium and sodium concentrations obtained from 12 cyst fluids were statistically correlated with creatinine concentrations. Evidence is presented indicating that micro cysts are initially apocrine in cell type and are more likely in continuity with the terminal ductal-lobular unit. It is postulated that apocrine cysts undergo cellular desquamation and lysis, becoming attenuated cysts. The ratio of potassium to sodium is altered by cell degradation rather than active secretory processes. Biochemical contents of cysts and nipple aspiration fluids are compared.
1）高钾低钠的顶泌（分泌性）囊肿，以及2）低钾高钠的扁平细胞囊肿。一些人认为顶泌细胞会主动分泌钾。细胞分型被认为很重要，因为顶泌囊肿更有可能双侧发生、多发、复发，并作为上皮细胞异型性的标志物。对通过乳头抽吸获得的58份囊液和28份导管分泌物进行了生化分析的回顾性研究。从12份囊液中测得的钾和钠浓度与肌酐浓度具有统计学相关性。有证据表明，微囊肿最初在细胞类型上是顶泌性的，并且更有可能与终末导管小叶单位相连。据推测，顶泌囊肿会经历细胞脱屑和溶解，从而变成扁平囊肿。钾与钠的比例是由细胞降解而非主动分泌过程改变的。对囊肿和乳头抽吸液的生化成分进行了比较。
