Yoshida K, Takahashi M, Takeuchi Y
J Bacteriol. 1969 Oct;100(1):162-6. doi: 10.1128/jb.100.1.162-166.1969.
Some strains of Staphylococcus aureus grew as compact colonies in Brain Heart Infusion-serum-soft agar but as diffuse colonies in a modified Staphylococcus 110-serum-soft agar. These strains were designated "pseudocompact." Strains showing compact-type colonial morphology in both media were designated "compact," whereas strains showing diffuse-type growth in both media were designated "diffuse." It was observed that the most recently isolated strains of S. aureus were of the pseudocompact type, whereas most stock culture strains tested were of the compact type. Using cultures recently isolated from clinical material, it was shown that pseudocompact strains convert to compact-type growth after prolonged incubation. Interconversion of compact, diffuse, and pseudocompact growth forms could be induced in vitro by appropriate cultural conditions, and conversion of growth type was also observed in vivo. Femoral abscesses produced in mice by four different compact-type strains showed conversion to diffuse or pseudocompact-type growth during the course of the infection.
某些金黄色葡萄球菌菌株在脑心浸液 - 血清软琼脂中生长为致密菌落，但在改良的葡萄球菌110 - 血清软琼脂中生长为扩散菌落。这些菌株被指定为“假致密型”。在两种培养基中均呈现致密型菌落形态的菌株被指定为“致密型”，而在两种培养基中均呈现扩散型生长的菌株被指定为“扩散型”。据观察，金黄色葡萄球菌最新分离出的菌株为假致密型，而测试的大多数保藏菌株为致密型。使用从临床材料中最近分离出的培养物表明，假致密型菌株在长时间培养后会转变为致密型生长。致密型、扩散型和假致密型生长形式的相互转化可通过适当的培养条件在体外诱导，并且在体内也观察到了生长类型的转变。由四种不同的致密型菌株在小鼠体内产生的股部脓肿在感染过程中显示出向扩散型或假致密型生长的转变。
