Wiley B B, Maverakis N H
J Bacteriol. 1968 Mar;95(3):998-1002. doi: 10.1128/jb.95.3.998-1002.1968.
There are at least two serologically distinct capsular types of coagulase-positive Staphylococcus aureus. Until now, unequivocal evidence for encapsulation of the Smith diffuse variant was lacking. However, the data presented in this paper provide definitive details of encapsulation of the Smith strain. A marked difference in ld(50) values for the two serologically distinct capsular types of S. aureus was demonstrated. The paradoxical behavior of these two strains suggested that the host was resistant to one and was susceptible to the other. A survey of the carriage incidence in mice for staphylococci and staphylococcal capsular antibodies disclosed the presence of staphylococci and capsular antibodies in these animals. The capsular antibodies detected were reactive against only one of the capsular types of S. aureus. None of the sera from the mice surveyed possessed capsular antibodies against the Smith diffuse variant, but the average incidence for the capsular antibodies against the wound mucoid type was 46%. We postulated that the susceptibility of the mice to the Smith diffuse variant was caused by the absence of protective, type-specific capsular antibodies. Conversely, the resistance of the mice to the wound mucoid staphylococci may have been a result of the presence of type-specific capsular antibodies.
凝固酶阳性金黄色葡萄球菌至少有两种血清学上不同的荚膜类型。到目前为止，缺乏关于史密斯弥漫变异株形成荚膜的确切证据。然而，本文提供的数据给出了史密斯菌株形成荚膜的确切细节。已证实两种血清学上不同的金黄色葡萄球菌荚膜类型的半数致死剂量（ld50）值存在显著差异。这两种菌株的矛盾行为表明宿主对其中一种有抗性，而对另一种敏感。一项对小鼠葡萄球菌携带率和葡萄球菌荚膜抗体的调查发现这些动物体内存在葡萄球菌和荚膜抗体。检测到的荚膜抗体仅对金黄色葡萄球菌的一种荚膜类型有反应。所调查小鼠的血清中没有针对史密斯弥漫变异株的荚膜抗体，但针对伤口黏液型荚膜抗体的平均发生率为46%。我们推测小鼠对史密斯弥漫变异株敏感是由于缺乏保护性的、型特异性荚膜抗体。相反，小鼠对伤口黏液型葡萄球菌的抗性可能是型特异性荚膜抗体存在的结果。
