瘤型麻风患者蛋白质的电泳图谱。

Electrophoretic pattern of proteins in lepromatous leprosy.

作者信息

Baji P S, Kher J R, Ganeriwal S K, Reddy B V, Bulakh P M

出版信息

Lepr India. 1982 Jan;54(1):82-94.

Abstract

Serum total proteins and the various protein fractions were studied in fifty cases of lepromatous leprosy and in eleven cases of lepromatous leprosy with lepra reaction. The study revealed a significant increase in serum total proteins in both lepromatous leprosy and lepra reaction groups, when compared with normal healthy subjects. The percentage rise was found to be 14.5% and 22.95% for lepromatous leprosy and lepra reaction respectively. The globulin fraction showed a significant elevation, while albumin showed a decrease. Thus a reversal of A/G ratio was observed in both the disease groups. Alpha-1 and Alpha-2 globulins were found to be significantly increased in both the disease groups. Beta globulins did not reveal any significant alteration. It was interesting to note the presence of an additional globulin fraction in seventeen patients of lepromatous leprosy and two cases of lepra reaction. Gammaglobulin showed a significant rise in lepromatous leprosy (56.16%) and in lepra reaction (60.72%). The significance of the above findings are discussed in the light of available literature.

摘要

对50例瘤型麻风患者及11例伴有麻风反应的瘤型麻风患者的血清总蛋白及各种蛋白组分进行了研究。研究发现，与正常健康受试者相比，瘤型麻风组和麻风反应组的血清总蛋白均显著增加。瘤型麻风组和麻风反应组的升高百分比分别为14.5%和22.95%。球蛋白组分显著升高，而白蛋白则降低。因此，在两个疾病组中均观察到A/G比值的逆转。在两个疾病组中均发现α1和α2球蛋白显著增加。β球蛋白未显示任何显著变化。有趣的是，在17例瘤型麻风患者和2例麻风反应患者中发现了一种额外的球蛋白组分。γ球蛋白在瘤型麻风组（56.16%）和麻风反应组（60.72%）中显著升高。根据现有文献对上述发现的意义进行了讨论。