Tursi A, Greaves M F, Torrigiani G, Playfair J H, Roitt I M
Immunology. 1969 Nov;17(5):801-11.
Thymus, spleen, lymph node and peripheral blood lymphocytes taken from mice treated with anti-lymphocyte globulin (ALG) showed a greatly diminished response to PHA . Recovery of circulating lymphocyte levels preceded recovery of responsiveness to PHA. The latter could be prevented by reinjection of ALG or by thymectomy. Grafts were rejected within a period equal to the normal rejection time after PHA responsiveness had recovered to a value of approximately 20 per cent of the normal. Thus the effect of ALG on thymus dependent lymphocytes in mice can be monitored by assessing the PHA sensitivity of peripheral white blood cells.
取自用抗淋巴细胞球蛋白（ALG）处理过的小鼠的胸腺、脾脏、淋巴结和外周血淋巴细胞对PHA的反应大大减弱。循环淋巴细胞水平的恢复先于对PHA反应性的恢复。再次注射ALG或进行胸腺切除可阻止后者的恢复。在PHA反应性恢复到正常水平的约20%后，移植物在与正常排斥时间相等的时间段内被排斥。因此，通过评估外周白细胞的PHA敏感性，可以监测ALG对小鼠胸腺依赖性淋巴细胞的作用。
