抑制剂诱导的大肠杆菌下移
Inhibitor-induced shift-downs in Escherichia coli.
作者信息
Nazar R N, Wong J T
出版信息
J Bacteriol. 1969 Nov;100(2):956-61. doi: 10.1128/jb.100.2.956-961.1969.
Abstract
A shift-down response in Escherichia coli cells has been brought about by moderate concentrations of azide or cyanide. Early events of the response included a preferential inhibition of ribonucleic acid relative to deoxyribonucleic acid synthesis, a degradation of polyribosomes, and an inhibition of protein synthesis followed by a transient relief. These changes were entirely comparable to those observed with nutrient-induced shift-downs. The influences of various nutrient supplements on an azide shift-down were examined, and methionine was found to relieve effectively the inhibition of ribonucleic acid synthesis in some strains of cells.
摘要
中等浓度的叠氮化物或氰化物可使大肠杆菌细胞产生降速反应。该反应的早期事件包括相对于脱氧核糖核酸合成，核糖核酸优先受到抑制、多核糖体降解、蛋白质合成受到抑制，随后短暂缓解。这些变化与营养物质诱导的降速反应中观察到的变化完全可比。研究了各种营养补充剂对叠氮化物降速反应的影响，发现甲硫氨酸可有效缓解某些细胞菌株中核糖核酸合成的抑制。
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