羟基脲的氧化产物氨甲酰氧基脲的一些生物学效应。
Some biological effects of carbamoyloxyurea, an oxidation product of hydroxyurea.
作者信息
Rosenkranz H S
出版信息
J Bacteriol. 1970 Apr;102(1):20-3. doi: 10.1128/jb.102.1.20-23.1970.
Abstract
Carbamoyloxyurea, an oxidation product of hydroxyurea, is bactericidal for Escherichia coli. Drug-induced killing is independent of cellular metabolism; ribonucleic acid and protein syntheses are the processes most affected, and the lethal action is accompanied by degradation of cellular deoxyribonucleic acid. In all of these effects the drug differs from hydroxyurea, a primarily bacteriostatic agent that inhibits deoxyribonucleic acid synthesis, whose lethal action ultimately depends on cellular activity.
摘要
氨甲酰氧基脲是羟基脲的一种氧化产物，对大肠杆菌具有杀菌作用。药物诱导的杀伤作用与细胞代谢无关；核糖核酸和蛋白质合成是受影响最大的过程，其致死作用伴随着细胞脱氧核糖核酸的降解。在所有这些作用方面，该药物不同于羟基脲，羟基脲是一种主要抑制脱氧核糖核酸合成的抑菌剂，其致死作用最终取决于细胞活性。
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