Cerklewski F L
J Nutr. 1979 Oct;109(10):1703-9. doi: 10.1093/jn/109.10.1703.
Confirmed pregnant female albino rats received a purified diet containing either 12 or 120 ppm zinc with or without lead (0 to 500 ppm) from day 0 gestation through day 16 of lactation. An 11% reduction in dam weight gain during gestation and a 12% reduction in average pup weight in rats fed the low zinc plus lead diet was markedly different compared to controls not receiving lead and lead supplemented rats receiving supplemental zinc. Milk lead concentration was reduced in rats receiving additional dietary zinc and lead which was reflected in a 15% reduction in pup tibia lead concentration, a 20% reduction in inhibition of pup liver delta-aminolevulinic acid dehydratase activity and a 31% reduction in pup blood porphyrin concentration. Some of the beneficial effects of supplemental zinc on lead toxicity of pups may be explained by a reduction of both liver lead (40%) and blood lead (32%) concentration of dams. However an interaction between lead and zinc at the placental and mammary barriers must also be considered. The results of this study suggest that nutritional status of zinc may be an important factor in modifying lead burden of infants borne by women occupationally and environmentally exposed to lead.
已确认怀孕的雌性白化大鼠从妊娠第0天到哺乳期第16天，接受含12 ppm或120 ppm锌且添加或不添加铅（0至500 ppm）的纯化饮食。与未接受铅的对照组和接受补充锌的铅补充大鼠相比，喂食低锌加铅饮食的大鼠在妊娠期母鼠体重增加减少11%，平均幼崽体重减少12%，差异显著。接受额外膳食锌和铅的大鼠乳汁铅浓度降低，这反映在幼崽胫骨铅浓度降低15%、幼崽肝脏δ-氨基乙酰丙酸脱水酶活性抑制降低20%以及幼崽血卟啉浓度降低31%。补充锌对幼崽铅毒性的一些有益作用可能是由于母鼠肝脏铅浓度（40%）和血铅浓度（32%）均降低所致。然而，还必须考虑铅和锌在胎盘和乳腺屏障处的相互作用。本研究结果表明，锌的营养状况可能是影响职业和环境接触铅的女性所生婴儿铅负荷的一个重要因素。
