膳食硒对大鼠铅毒性的影响。

Influence of dietary selenium on lead toxicity in the rat.

作者信息

Cerklewski F L, Forbes R M

出版信息

J Nutr. 1976 Jun;106(6):778-83. doi: 10.1093/jn/106.6.778.

DOI:10.1093/jn/106.6.778

Abstract

An investigation of the influence of dietary selenium (0.015, 0.05, 0.50, 1.0 ppm) on toxicity of dietary lead (0 and 200 ppm) in the young male rat indicated that selenium was mildly protective against the toxic effects of lead, but only up to 0.50 ppm selenium. At the excess selenium dietary level an exaggeration of lead toxicity was observed. Criteria employed to judge the effects of dietary selenium on lead toxicity included tissue lead concentration and urinary delta-aminolevulinic acid excretion. One exception to the exaggeration effect of excess selenium on lead toxicity was the protective effect of selenium on liver delta-aminolevulinic acid dehydratase activity. Since lead depressed kidney selenium concentration, lead may act as an antagonist to selenium metabolism.

摘要

一项关于膳食硒（0.015、0.05、0.50、1.0 ppm）对幼龄雄性大鼠膳食铅（0和200 ppm）毒性影响的研究表明，硒对铅的毒性作用有轻微的保护作用，但仅在硒含量达0.50 ppm时有效。在膳食硒过量的水平下，观察到铅毒性增强。用于判断膳食硒对铅毒性影响的标准包括组织铅浓度和尿δ-氨基乙酰丙酸排泄量。过量硒对铅毒性的增强作用存在一个例外，即硒对肝脏δ-氨基乙酰丙酸脱水酶活性具有保护作用。由于铅会降低肾脏中的硒浓度，铅可能是硒代谢的拮抗剂。