Cartlidge N E, Crombie A L, Anderson J, Hall R
Br Med J. 1969 Dec 13;4(5684):645-7. doi: 10.1136/bmj.4.5684.645.
Assessment was made of 5% local guanethidine in treating eye manifestations in euthyroid patients with either treated thyrotoxicosis or ophthalmic Graves's disease. In a double-blind crossover study guanethidine caused greater improvement in lid retraction than a control solution. A long-term study showed that this improvement was maintained. A much lower incidence of side-effects was noted with 5% guanethidine than with 10% solution.
对5%的局部胍乙啶治疗甲状腺功能正常但曾患甲状腺毒症或Graves眼病的患者眼部表现进行了评估。在一项双盲交叉研究中，胍乙啶比对照溶液能更有效地改善眼睑退缩。一项长期研究表明这种改善得以维持。与10%的溶液相比，5%胍乙啶的副作用发生率要低得多。
