大肠杆菌的6-磷酸葡萄糖酸内酯酶突变体和一个麦芽糖蓝色基因。
6-phosphogluconolactonase mutants of Escherichia coli and a maltose blue gene.
作者信息
Kupor S R, Fraenkel D G
出版信息
J Bacteriol. 1969 Dec;100(3):1296-301. doi: 10.1128/jb.100.3.1296-1301.1969.
Abstract
Mutants lacking an enzyme of the oxidative branch of the hexose monophosphate shunt, 6-phosphogluconolactonase (pgl), have been selected as a new class of glucose-negative derivatives of a phosphoglucose isomerase (pgi) mutant. Glucose negativity is not as complete as in mutants lacking phosphoglucose isomerase and glucose-6-phosphate dehydrogenase. Pgi(+), pgl(-) strains have been constructed by transduction and grow almost normally on glucose. Genetic mapping shows that pgl lies between chlD and att-lambda, in the same position as and identical with a blu gene described by Adhya and Schwartz. These blu mutants grown on maltose were recognized by their property to turn blue after treatment with iodine. It is not known how phosphogluconolactonase deficiency causes this reaction; it might be related to accumulation of 6-phosphogluconolactone.
摘要
缺乏己糖磷酸支路氧化分支的一种酶——6-磷酸葡糖酸内酯酶（pgl）的突变体，已被选作磷酸葡糖异构酶（pgi）突变体的一类新的葡萄糖阴性衍生物。葡萄糖阴性不像缺乏磷酸葡糖异构酶和葡萄糖-6-磷酸脱氢酶的突变体那样完全。通过转导构建了Pgi(+)、pgl(-)菌株，它们在葡萄糖上几乎能正常生长。遗传图谱显示pgl位于chlD和att-λ之间，与Adhya和Schwartz描述的一个blu基因处于相同位置且相同。这些在麦芽糖上生长的blu突变体，其特性是在用碘处理后会变蓝。尚不清楚磷酸葡糖酸内酯酶缺乏是如何引起这种反应的；这可能与6-磷酸葡糖酸内酯的积累有关。
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