大肠杆菌K-12中的malB区域：新突变的特征分析
malB region in Escherichia coli K-12: characterization of new mutations.
作者信息
Hofnung M, Hatfield D, Schwartz M
出版信息
J Bacteriol. 1974 Jan;117(1):40-7. doi: 10.1128/jb.117.1.40-47.1974.
Abstract
Phenotypic characterization and mapping of more than 50 Mal(-) mutations located in the malB region lead one to divide the site for Mal(-)lambdas mutations (formerly called gene malB) in that region, into two adjacent genetic segments malJ and malK. malJ and malK are both involved in maltose permeation. It is suggested that (i) malK and lamB, the only known gene specifically involved in phage lambda adsorption (20), constitute an operon of polarity malK lamB. (ii) malJ and malK correspond to two different genes, and (iii) a promoter for the malK lamB operon is located between malJ and malK. Since lambda receptors and maltose permease are inducible by maltose and absent in malT mutants, it is likely that the expression of the malK lamB operon is controlled by the product of gene malT, the positive regulatory gene of the maltose system.
摘要
对位于malB区域的50多个Mal(-)突变进行表型特征分析和定位后，人们将该区域中Mal(-)λ突变位点（以前称为基因malB）划分为两个相邻的基因片段malJ和malK。malJ和malK都参与麦芽糖通透。有人提出：(i) malK和lamB是唯一已知的专门参与噬菌体λ吸附的基因(20)，它们构成了一个具有极性的malK lamB操纵子。(ii) malJ和malK对应于两个不同的基因，并且(iii) malK lamB操纵子的启动子位于malJ和malK之间。由于λ受体和麦芽糖通透酶可被麦芽糖诱导，并且在malT突变体中不存在，因此malK lamB操纵子的表达很可能受基因malT（麦芽糖系统的正调控基因）产物的控制。
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