大肠杆菌遗传图谱中麦芽糖A区域的无义突变
Nonsense mutations in the maltose A region of the genetic map of Escherichia coli.
作者信息
Hatfield D, Hofnung M, Schwartz M
出版信息
J Bacteriol. 1969 Dec;100(3):1311-5. doi: 10.1128/jb.100.3.1311-1315.1969.
Abstract
The isolation of one amber mutation in malQ, one ochre mutation in malP, and seven amber mutations in malT is reported. A study of their phenotypic expressions in the presence of the amber suppressor su(III) and the ochre suppressor su(c) suggests that (i) malQ is the structural gene for amylomaltase; (ii) malQ and the structural gene for maltodextrin phosphorylase, malP, belong to the same operon; (iii) the malT product, which promotes the expression of the malP-malQ operon, is a protein synthesized in limiting amounts by the wild-type strain.
摘要
已报道在malQ中分离出一个琥珀突变、在malP中分离出一个赭石突变以及在malT中分离出七个琥珀突变。对它们在琥珀抑制基因su(III)和赭石抑制基因su(c)存在情况下的表型表达进行的研究表明：(i) malQ是淀粉麦芽糖酶的结构基因；(ii) malQ和麦芽糊精磷酸化酶的结构基因malP属于同一个操纵子；(iii) 促进malP-malQ操纵子表达的malT产物是野生型菌株以限量合成的一种蛋白质。
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