Nakata A, Peterson G R, Brooks E L, Rothman F G
J Bacteriol. 1971 Sep;107(3):683-9. doi: 10.1128/jb.107.3.683-689.1971.
The order of gene loci in the phoA-phoR region of the Escherichia coli K-12 linkage map was demonstrated to be lac phoA proC phoR. The end of the phoA locus corresponding to the amino terminus of alkaline phosphatase was shown to be the end nearer proC. Translation (and transcription) of phoA is therefore in the anticlockwise direction relative to the conventional E. coli linkage map.
大肠杆菌K-12连锁图谱中phoA-phoR区域的基因位点顺序被证明为lac phoA proC phoR。phoA位点对应碱性磷酸酶氨基末端的一端显示为更靠近proC的一端。因此,相对于传统的大肠杆菌连锁图谱,phoA的翻译(和转录)方向是逆时针的。