左旋多巴治疗帕金森病
Treatment of Parkinsonism with Laevo-dopa.
作者信息
Mawdsley C
出版信息
Br Med J. 1970 Feb 7;1(5692):331-7. doi: 10.1136/bmj.1.5692.331.
Abstract
Thirty-two patients with Parkinsonism were treated with L-dopa. Nine were markedly and 14 moderately improved. Twenty patients tolerated the drug well, derived definite improvement, and were treated for an average period of six months. Improvement was sustained during this period even though the average daily dosage of L-dopa was reduced. Dose-dependent side-effects occurred in 25 patients. It is suggested that dosage schedules should be flexible and tailored to the needs of each individual patient, and that treatment should be continued for six months before presuming it to be ineffective.It is concluded that L-dopa often ameliorates Parkinsonism for long periods, but its effect on the natural history of the disease is undertermined.
摘要
32例帕金森病患者接受了左旋多巴治疗。9例显著改善，14例中度改善。20例患者对该药耐受性良好，病情得到明确改善，平均治疗时间为6个月。在此期间，尽管左旋多巴的平均日剂量有所减少，但改善情况仍持续存在。25例患者出现剂量依赖性副作用。建议给药方案应灵活，根据每个患者的需求进行调整，并且在认为治疗无效之前应持续治疗6个月。得出的结论是，左旋多巴通常能长期改善帕金森病，但它对该疾病自然病程的影响尚不确定。
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本文引用的文献
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Treatment of Parkinson's syndrome with L-dopa. A double blind study.左旋多巴治疗帕金森综合征。一项双盲研究。
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