Gelman B B, Michaelson I A, Bornschein R L
J Toxicol Environ Health. 1979 Jul;5(4):683-98. doi: 10.1080/15287397909529780.
Neonatal rats were given aqueous lead acetate intragastrically from d 2-20 of life at doses of 0, 10, 50, and 225 mg Pb/kg.d. Blood Pb concentrations on d 21 were (mean +/- SE) 23 +/- 3 (control), 63 +/- 19, 246 +/- 55, and 994 +/- 223 microgram/100 ml, and brain Pb concentrations were 14 +/- 2, 60 +/- 5, 114 +/- 15, and 275 +/- 26 microgram/100 g, respectively. Growth was significantly depressed only in rats given the highest dose of Pb (225 mg/kg.d). Solvent-extractable lipofuscin pigment concentration of brain tissue progressively decreased over the 21-d duration of the experiment but was not significantly altered at any dose of Pb. Brain glutathione peroxidase, glucose-6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase activities were stimulated on d 20 at the maximal dose of Pb, but the activities of brain superoxide dismutases and catalase were not altered by Pb exposure. Locomotor activity was significantly increased in the male animals on d 20, but only at the highest dose of Pb. These results indicate that Pb toxicity in neonatal rats is not associated with accelerated in vivo lipid peroxidation in the brain, but that certain oxidant defense mechanisms in the brain are stimulated by Pb.
新生大鼠在出生后第2至20天经口灌胃给予醋酸铅水溶液，剂量分别为0、10、50和225 mg Pb/kg·d。第21天的血铅浓度（均值±标准误）分别为23±3（对照组）、63±19、246±55和994±223微克/100毫升，脑铅浓度分别为14±2、60±5、114±15和275±26微克/100克。仅给予最高剂量铅（225 mg/kg·d）的大鼠生长显著受到抑制。在实验的21天期间，脑组织中可通过溶剂提取的脂褐素色素浓度逐渐降低，但在任何铅剂量下均无显著变化。在第20天，给予最大剂量铅时，脑谷胱甘肽过氧化物酶、葡萄糖-6-磷酸脱氢酶和6-磷酸葡萄糖酸脱氢酶的活性受到刺激，但脑超氧化物歧化酶和过氧化氢酶的活性未因铅暴露而改变。在第20天，雄性动物的运动活性显著增加，但仅在最高铅剂量下。这些结果表明，新生大鼠的铅毒性与脑内体内脂质过氧化加速无关，但脑内某些抗氧化防御机制受到铅的刺激。
