Miller G D, Massaro T F, Granlund R W, Massaro E J
J Toxicol Environ Health. 1983 Jan;11(1):121-8. doi: 10.1080/15287398309530326.
The tissue distribution of lead (Pb) was examined in the neonatal rat intragastrically administered lead acetate (50 mg/kg, containing 210Pb) beginning on d 6 postpartum and thereafter at 3-d intervals to d 18. A time-dependent pattern of uptake was observed in bone, kidney, liver, and brain, while stomach, lung, heart, and spleen had no accumulation of Pb. The highest concentration of Pb at d 21 was detected in bone, and the least amount was found in blood and brain. Body weight was not significantly affected by the level of Pb exposure employed.
从出生后第6天开始，对新生大鼠进行胃内给予醋酸铅（50毫克/千克，含210Pb）处理，并在此后每隔3天持续至第18天，检测铅（Pb）的组织分布。在骨骼、肾脏、肝脏和大脑中观察到了随时间变化的摄取模式，而胃、肺、心脏和脾脏中没有铅的蓄积。在第21天时，骨骼中检测到的铅浓度最高，而血液和大脑中的铅含量最少。所采用的铅暴露水平对体重没有显著影响。
