L-甲基多巴肼对接受左旋多巴治疗患者血压的作用
Action of L- -methyldopa-hydrazine on the blood pressure of patients receiving levodopa.
作者信息
Calne D B, Petrie A, Rao S, Reid J L, Vakil S D
出版信息
Br J Pharmacol. 1972 Jan;44(1):162-4. doi: 10.1111/j.1476-5381.1972.tb07249.x.
Abstract
The blood pressure and pulse rate have been compared in a 'double blind, cross over' study involving twenty patients with idiopathic Parkinsonism receiving maximum tolerated dosage of levodopa with and without an extracerebral decarboxylase inhibitor, L-alpha-methyldopahydrazine. The supine and erect systolic pressures were significantly higher and the erect pulse rate significantly lower during administration of L-alpha-methyldopahydrazine. The implications of these observations are discussed.
摘要
在一项“双盲、交叉”研究中，对20例特发性帕金森病患者在服用最大耐受剂量左旋多巴时加用或不加用脑外脱羧酶抑制剂L-α-甲基多巴肼的情况下的血压和脉搏率进行了比较。服用L-α-甲基多巴肼期间，仰卧位和直立位收缩压显著升高，直立位脉搏率显著降低。对这些观察结果的意义进行了讨论。
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